Generic Name: Zonisamide
Zonegran (ZON-e-gran) is an antiepileptic drug that has been available in Japan for several years. Unrelated to other seizure-preventing medications, it was approved for use in the United States as an add-on drug for adults with partial seizures in 2000. It interacts with Dilantin and Tegretol, Carbatrol and other forms of carbamazepine, Depakene/Depakote and phenobarbital. The most frequently reported side effects in clinical trials were sleepiness and fatigue. Less common side effects include kidney stones, reduced sweating, rash, loss of appetite, depression, difficulty with concentration and speech. Reports suggest this drug may have special benefit against myoclonic seizures; it is now being tested against primary generalized tonic clonic seizures. Safety in pregnancy has not been established. Women who are taking this medication and who wish to become pregnant should discuss treatment options with their physicians before the pregnancy begins.
Not everyone experiences side effects. There may be other side effects not appearing above. For a complete list, consult your doctor, nurse or pharmacist. More detailed sources of information on side effects include the drug’s prescribing information sheet, the Physician’s Desk Reference or pharmaceutical company which produces the drug.
Link to product information here.