Gabitril
Gabitril®
Generic Name: Tiagabine HDl
Uses
Treatment of partial seizures as
add-on therapy in adults and children 12 years and older.
How it works
We think Gabitril® works
by helping one of the brain chemicals (GABA) to work better. It is well
absorbed when taken by mouth and is best taken with food to avoid sharp rises
in blood levels. It is broken down primarily by the liver. The half life is 7
to 9 hours in adults.
Forms of the medicine
Gabitril® tablets are
available in four dosage strengths; 2, 4, 12 and 16 milligrams
Dosing
Gabitril® is given by
mouth. It is given twice or four times per day with food. Dosing amounts and
frequency of dosing will be decided by the treating physician. Dosing will
usually start with about 4 milligrams per day and will likely be increased over
time.
Side Effects
The most common side effects include
sedation, fatigue or muscle weakness, nervousness, headache, fatigue,
irritability, difficulty with concentration, tremor, and dizziness.
Information for Pregnant women and
nursing mothers
Safety in pregnancy has not been
established. It is known that women taking antiepileptic drugs have a higher
incidence of birth defects than women who are not. Women who are taking this
medication and who wish to become pregnant should discuss treatment options
with their physicians before the pregnancy begins. Gabitril® is
passed into breast milk.
Drug Interactions
Dilantin®, Tegretol®,
Mysoline® and Phenobarbital® can decrease Gabitril®
levels.
Care during treatment with Gabitril®
You should take the medicine as
prescribed by your physician. If you are late in taking a dose by 2-3 hours,
you should take it. If you miss a dose altogether, you should wait until the
next dose and take the prescribed amount, or consult your physician. Report any
unusual rashes or other side effects. As a rule, antiepilepsy drugs should not
be abruptly discontinued because of the possibility of increasing seizure
frequency.
Possible Contraindications to the
use of Gabitril®
A history of an allergic reaction to
tiagabine.
Not everyone experiences side effects. There may be other side effects not appearing above. For a complete list, consult your doctor, nurse, or pharmacist. More detailed sources of information on side effects include the drug’s prescribing information sheet, the Physician’s Desk Reference, or pharmaceutical company which produces the drug.